The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Studies on Constituents of Higher Fungi of Korea(XXXIV) -Antitumor Components of Ramaria formosa-

한국산(韓國産) 고등(高等) 균류(菌類)의 성분(成分) 연구(硏究)(제34보) -붉은싸리버섯의 항암(抗癌) 성분(成分)-

  • Yoo, In-Sook (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Woo, Myoung-Sik (College of Pharmacy, Sook Myung Women's University) ;
  • Choi, Eung-Chil (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Kim, Byong-Kak (Department of Microbial Chemistry, College of Pharmacy, Seoul National University)
  • 유인숙 (서울대학교 약학대학 미생물약품화학교실) ;
  • 우명식 (숙명여자대학교 약학대학) ;
  • 최응칠 (서울대학교 약학대학 미생물약품화학교실) ;
  • 김병각 (서울대학교 약학대학 미생물약품화학교실)
  • Published : 1982.12.30
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Abstract

To investigate antitumor components of Korean higher fungi, the carpophores of Ramaria formosa $(Fr.)Qu\acute{e}l$. were collected in Gang Won Province and extracted with hot water. The extract was concentrated and precipitated by four volumes of ethanol. The precipitate was centrifugated and purified by dialyzing through Visking tube and a protein-bound polysaccharide fraction was obtained. The fraction was tested for antitumor activity against sarcoma 180 implanted in mice. The tumor inhibition ratio of the fraction was 66% in the dose of 50mg/kg/day for the period of ten days. The tumor in two of the eight mice was completely regressed. The components of the fraction were found to be a polysaccharide and a protein. The chemical analysis of the fraction showed that the polysaccharide moiety consisted of four monosaccharides and that the protein moiety contained fourteen amino acids.

한국산 고등 균류의 항암성분을 연구하고자 강원도에서 채집한 붉은싸리버섯 Ramaria formosa $(Fr.)Qu\acute{e}l$. 로 부터 추출, 농축, 침전시킨후, 그 침전을 원심분리하고 Visking tube를 사용하여 정제한 결과 단백질-다당체를 얻었다. 이 물질의 항암 효과를 쥐에 이식된 sarcoma 180에 대하여 시험하였으며 50 mg/kg/day의 용량으로 10일간 투여한 결과 그 종양억제율은 66%였다. 8마리중 2마리에서는 완전한 종양 퇴화를 관찰하였다. 이 항암 성분을 화학적으로 분석하여 그 다당체의 대부분은 4종의 단당으로 구성되었고 단백질 부분은 14종의 아미노산으로 구성되어 있음을 밝혔다.

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