Studies on Constituents of Higher Fungi of Korea(XXXIII) -Antitumor Components of Trametes sanguinea-

한국산(韓國産) 고등(高等) 균류(菌類)의 성분(成分) 연구(硏究)(제33보) -간버섯의 항암(抗癌) 성분(成分)-

To find antitumor components with low toxicity from natural resources, antitumor test of the water extract of the carpophores of Trametes sanguinea (L. ex Fr.) Lloyd. was undertaken. The carpophores of this fungus were collected in Gyeong Gi Province and extracted with hot water. The extract was purified by dialyzing through Visking tube and a protein-bound polysaccharide fraction was obtained. The fraction was tested for antitumor activity against sarcoma 180 implanted in mice. The tumor inhibition ratio of the fraction against the tumor was 72.4% at the dose of 10mg/kg/day for the period of ten days. The tumor in one of the eight mice was completely regressed. The antitumor components were found to be a polysaccharide and a protein. The hydrolysis of the polysaccharide moiety yielded three monosaccharides, and from the hydrolysate of the protein moiety 13 amino acids were identified.

한국산 고등균류의 성분중에서 항암성분을 탐색하고자, 경기도 수원에서 채집한 간버섯 Trametes sanguinea (L. ex Fr.) Lloyd.로 부터 무미 무취인 짙은 갈색 분말을 추출 분리하였다. 이 물질은 마우스에 이식된 sarcoma 180에 대해 높은 저지율을 보였고, 그 저지작용은 이 물질의 치료적인 투여에 의해서 나타났다. 이 물질의 성분은 다당류와 단백질이었으며, 다당류는 fucose, glucose와 galactose의 3종의 당을 함유하였다. 단백질 분획은 13종의 아미노산으로 구성되었으며, 특히 산성 아미노산이 많은 반면에 염기성 아미노산은 적었다.