칼슘이 결장뉴 K-경축에 미치는 영향

Effect of Calcium Ion on K-contracture in Guinea Pig's Taenia Coli

  • 조성일 (중앙대학교 의과대학 생리학교실) ;
  • 엄대용 (중앙대학교 의과대학 생리학교실) ;
  • 이상돈 (중앙대학교 의과대학 생리학교실)
  • Cho, Sung-Il (Department of Physiology, College of Medicine, Chung-ang University) ;
  • Uhm, Dae-Yong (Department of Physiology, College of Medicine, Chung-ang University) ;
  • Rhee, Sang-Don (Department of Physiology, College of Medicine, Chung-ang University)
  • 발행 : 1982.06.30

초록

The in vitro experiments for isometric contraction were done to investigate the different action mechanism of calcium ion on phasic and tonic components of K-contracture in guinea pig's taenia coli. The results were as follows: 1) The degrees of K-contracture were increased gradually from 4 mM to 15, 20, 40 & 100 mM of$[K^+]_0$. The maximal developed tension in tonic component was observed in 100 mM of $[K^+]_0$. 2) The phasic components were not so affected by 2, 4, 8 & 16 mM of $[Ca^{++}]_0$ in 100 mM K-contracture, but the tonic components were gradually increased in a dose-responsive manner. 3) The K-contracture was not influenced by norepinephrine, 1 mg/l, but was completely abolished by verapamil, 2 mg/l. 4) The phasic component was little affected by verapamil, 0.01 mg/l, 0.1 mg/l, and 1 mg/l, but the tonic component was completely disappeared at the concentration of verapamil 1 mg/l. The above results suggest that $[Ca^{++}]_0.$ primarily affected the tonic component than the phasic component of K-contracture in guinea pig's taenia coli.

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