7-Alkyl-1-carboxyphenazine derivatives, bearing butyl or octyl group, were synthesize by the reaction of anthranilic acid with 3-nitroalkylbenzene, prepared from aniline and alcohols as starting materials through alkylation of 3-nitro-4-aminoalkylbenzene. And the products were also identified by elementary analysis, IR and NMR spectra. Surface tension of these derivatives in aqueous solution was determined. And also Antibiotic activity of these derivatives was tested, using Gram positive and negative bacillus and fungi. It showed that the antibiotic activity of these alkyl-substituted 1-carboxyphenazine derivatives was stronger than that of the 1-carboxyphenazine.
Aniline과 alcohol류에서 4-aminoalkylbenzene을 合性하여, 이것을 아세틸化, 니트로化, 加水分解하여 3-nitro-4-aminoalkylbenzene을 얻고 아미노기 이탈반응을 통해 3-nitroalkylbenzene을 合成하여 anthranilic acid와 반응시켜 7-alkyl-1-carboxyphenazine 유도체를 合成하였다. 生成物은 元素分析, IR, NMR 스펙트럼으로 確認하였다. 이들 誘導體들의 水溶液에 대한 表面張力을 測定하였고, 아울러 Gram 陽性菌, Gram 陰性菌, 眞性菌에 대한 抗菌性을 調査하였다. 試驗結果 alkyl기가 치환된 phenazine 誘導體의 抗菌性은 alkyl기가 없는 1-carboxyphenazine 보다 强한 것으로 나타났다.