약학회지 (YAKHAK HOEJI)
- 제25권3호
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- Pages.101-108
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- 1981
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
가토에 있어서 Capsaicin의 흡수 및 배설에 관한 연구
Study on the Absorption and Excretion of Capsaicin in Rabbits
초록
Quantitative determination of capsaicin in biological fluid was investigated. The pharmacokinetic study of capsaicin in rabbits was performed by high-pressure liquid chromatography, equipped with a microparticulate reversed-phase column and a fixed wavelength detector. Elution was carried out using methanolwater(70:30). It allows the quantitative determination at 8-400 ng level. When single dose of capsaicin(4mg/kg) was given to rabbits intravenously, the elimination phase was extremely short with average half-life to 17.35 minute. Urine excretion of capsaicin itself during first 2 hours after intravenous administration (4mg/kg) was 0.004-0.04% of the administered amount. The maximum plasma concentration of capsaicin after oral administration (300mg/kg) was
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