YAKHAK HOEJI (약학회지)
- Volume 25 Issue 3
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- Pages.101-108
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- 1981
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Study on the Absorption and Excretion of Capsaicin in Rabbits
가토에 있어서 Capsaicin의 흡수 및 배설에 관한 연구
Abstract
Quantitative determination of capsaicin in biological fluid was investigated. The pharmacokinetic study of capsaicin in rabbits was performed by high-pressure liquid chromatography, equipped with a microparticulate reversed-phase column and a fixed wavelength detector. Elution was carried out using methanolwater(70:30). It allows the quantitative determination at 8-400 ng level. When single dose of capsaicin(4mg/kg) was given to rabbits intravenously, the elimination phase was extremely short with average half-life to 17.35 minute. Urine excretion of capsaicin itself during first 2 hours after intravenous administration (4mg/kg) was 0.004-0.04% of the administered amount. The maximum plasma concentration of capsaicin after oral administration (300mg/kg) was
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