Archives of Pharmacal Research
- 제4권1호
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- Pages.43-51
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- 1981
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Interaction of flavins and some alcohols on the molecular level
- Yu, Byung-Sul (College of Pharmacy, Seoul National University) ;
- Chung, Hyun-Ho (College of Pharmacy, Seoul National University) ;
- Lee, Sang-Jong (College of Pharmacy, Seoul National University) ;
- Kim, Yang-Bae (College of Pharmacy, Seoul National University) ;
- Kim, Chong-Kook (College of Pharmacy, Seoul National University)
- 발행 : 1981.06.01
초록
The effect of some alcohols on the riboflavin derivatives in non-polar solvent was studied by various spectroscopic method in order to support the view point that alcohol may directly interect with the isoalloxazine moiety of FAD, the coenzyme of D-amino-acid oxidase. The most possible association complex between alcohol and riboflavin is the 1:1 complex through the 2-C carbonyl function of the isollaxazine ring nd the hydroxyl proton of alcohol. It is appeared that methanol has a larger association constant than any other alcohols, and the association constant decreases with the carbon number increases and being bulkier in the alkyl group of alcohols.
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