생약학회지 (Korean Journal of Pharmacognosy)
- 제12권4호
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- Pages.203-207
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- 1981
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
산조인의 플라보노이드 및 사포닌의 진정작용
Sedative Action of Flavonoids and Saponin from the Seeds of Zizyphus vulgaris var. spinosus Bunge
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Shin, Kuk-Hyun
(Natural Products Research Institute, Seoul National University) ;
- Woo, Won-Sick (Natural Products Research Institute, Seoul National University) ;
- Lee, Chung-Kyu (Natural Products Research Institute, Seoul National University)
- 발행 : 1981.12.30
초록
The acute toxicity and sedative activity of flavonoids and saponin isolated from Zizyphus seeds have been evaluated in mice. All the compounds elicited potentiation of hexobarbital-induced hypnosis, inhibition of ladder-climbing and caffeine-induced hyperactivity. Swertisin was the most potent of all flavonoids tested. The potency of saponin in these tests was found to be higher than that of swertisin. The activities in rotarod test and electroshock seizure test, on the other hand, were relatively weak or nil. From these findings it was suggested that flavonoids and saponin from Zizyphus seeds have neuroleptic activity without anticonvulsant or muscle relaxant activity accompanied by neurological deficit.
키워드