대한약리학회지 (The Korean Journal of Pharmacology)
- 제17권2호
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- Pages.63-67
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- 1981
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- 0377-9459(pISSN)
Acetazolamide가 Furosemide의 이뇨작용에 미치는 영향
Effect of Acetazolamide on the Diuretic Action of Furosemide in Rabbits
- Yeom, Yoon-Hee (Department of Pharmacology, Catholic Medical College) ;
- Lee, Jong-Hwa (Department of Pharmacology, Catholic Medical College) ;
- Kim, In-Soon (Department of Pharmacology, Catholic Medical College) ;
- Kim, Ock-Nyu (Department of Pharmacology, Catholic Medical College) ;
- Cho, Kyu-Chul (Department of Pharmacology, Catholic Medical College)
- 발행 : 1981.12.30
초록
Furosemide의 이뇨작용에 대한 acetazolamide의 영향을 알아보고자 토끼를 4군으로 나누어 saline(0.5ml/kg), acetazolamide (10mg/kg), furosemide (0.5mg/kg), acetazolamide (10mg/kg)+furosemide(0.5mg/kg)를 각각 정맥주사하였다. 1) Acetazolamide와 furosemide 병합투여시 furosemide를 단독투여했을 때의 뇨량, 뇨중 전해질 배설량에 비하여 유의한 감소를 보였다. 2) Acetazolamide와 furosemide 병합투여시와 furosemide를 단독투여시의 뇨중 전해질과 뇨량의 fraxtional excretion rate를 비교하면, 병합투여시에 감소되어 나타났으며 뇨중전해질보다 뇨량에서 그 정도가 심하였다. 3) Acetazolamide와 furosemide 병합투여시 뇨 pH가 furosemide 단독투여시보다 높게 나타났다. 4) 뇨중
Effect of acetazolamide on the diuretic action of furosemide was investigated in rabbits. The rates of urine flow and excretion of salts were significantly reduced when furosemide (0.5 mg/kg) was administered with acetazolamide (10 mg/kg) compared to the diuretic response of the single furosemide (0. 5 mg/kg) administration. Reduction in the fractional excretion rate of urine volume was more pronounced than the fractional excretion rate of salts. The results suggest that reduction of diuretic action on furosemide by combined administration of acetazolamide is probably due elevated urinary pH and interference in the mechanism of inhibition of chloride transport in the ascending Henle's limb.
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