약학회지 (YAKHAK HOEJI)
- 제24권1호
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- Pages.1-10
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- 1980
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Mycobacterium smegmatis를 이용한 Viomycin의 내성 및 작용 기전에 관한 연구
Studies on the Mechanism of Resistance to and Mode of Action of Viomycin in Mycobacterium smegmatis
초록
Viomycin inhibited polypeptide biosynthesis, initiation complex formation and translocation of peptidyl-tRNA on ribosomes derived from a sensitive strain of Mycobacterium smegmatis (R-15), but not significantly on ribosomes from viomycin-resistant mutants(R-31 and R-43). The inhibition of translocation was stronger than that of initiation complex formation in the sensitive strain. The binding of [
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