Journal of Pharmaceutical Investigation
- 제10권4호
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- Pages.23-29
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- 1980
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Ampicillin-polyvinylpyrrolidone 공침물(共沈物)에 관한 약제학적(藥劑學的) 연구(硏究)
Pharmaceutical Study on Ampicillin-polyvinylpyrrolidone Coprecipitate
- Kim, Johng-Kap (College of Pharmacy, Chung-Ang University) ;
- Eam, Jin-Soop (College of Pharmacy, Chung-Ang University)
- 발행 : 1980.12.20
초록
Ampicillin-polyvinylpyrrolidone coprcipitates, 1 : 5 ratio w/w, were prepared by the solvent method to increase the solubility and dissolution rate of ampicillin anhydrous. It was found that the solubility and dissolution rate of the coprecipitate were higher than that of ampicillin anhydrous, mechanical mixture of ampicillin and polyvinylpyrrolidone in powder state. The intrinsic, dissolution rate, G, are
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