Hepatic Drug Clearance of Animal in Disease States I -Hepato-biliary Transport of Bromphenol Blue in Acute $CCl_4$ Intoxicated Rabbits-

병태동물(病態動物)에서의 약물(藥物)의 Hepatic Clearance에 관한 연구(硏究) I -병태가토(病態家兎)에서의 Bromphenol Blue의 간담수송(肝膽輸送)-

Bromphenol blue (BPB) was studied with rabbits in normal and disease states to understand the basic principles of hepato-biliary transport process, and the effect of disease states on the drug disposition. The time course of plasma concentration and of biliary excretion was studied in normal and $CCl_4$ intoxicated rabbits. A conspicuous retention of BPB clearance from the plasma was observed, and the slope of the first-phase of plasma curve was decreased in the intoxicated rabbits. The shape of biliary excretion was same in normal and intoxicated states, but the amount of BPB excreted into bile in the intoxicated states was much smaller than in normal states. A relationship was found which enables one to predict the pattern of uptake of BPB by the liver, and the pattern of excretion into the bile in normal states, but was not in $CCl_4$ intoxicated states. It may be that the application of this experiments would extend the effect of disease states on the drug disposition.