Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antihypertensive Activities of Diterpenoid (16,17-dihydroxy-16-${\beta}-(-)$-kaurane-19-oic acid) in Siegesbeckiae pubescens Against Okamoto-Spontaneously Hypertensive Rats

희첨 성분중 디터핀 물질이 오까모토 고혈압 모델 쥐에 미치는 혈압 강하작용

  • Kim, Jae-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Yu, Jae-Chun (Natural Products Research Institute, Seoul National University) ;
  • Chang, Il-Moo (Natural Products Research Institute, Seoul National University) ;
  • Lee, Jong-Heun (College Dentistry, Seoul National University) ;
  • Kim, Joong-Soo (College Dentistry, Seoul National University)
  • Published : 1980.09.30
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Abstract

As a folkloric medicine, Siegesbeckia pubescens has been used for treatment of brain stroke and hypertension. Diterpene compound, 16,17-dihydroxy 16-${\beta}-(-)$ kaurane-19-oic acid, was isolated from the plant. Its potential antihypertensive activity was evaluated againstan animal model of hypertension, Okamoto-SHR. When diterpene compound with dose of 50mg/kg/day was orally administered, it exhibited mild antihypertensive activity comparable with propranolol administration dose of 75mg/kg/day.

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