Studies on the Development of Antifungal Agents(I) -Antifungal Activity of Salicylaldehyde-o-phenylenediimine-

항사상균제(抗絲狀菌劑) 개발(開發)에 관한 연구(硏究)( I ) -Salicylaldehyde-o-phenylenediimine의 항진균작용(抗眞菌作用)-

The antifungal activity of salicylaldehyde-o-phenylenediimine, a derivative of Schiff base, was studied in vitro against various species of fungi, especially, dermatophytes. The antifungal tests were performed according to the tube-dilution method, and all subcultures were incubated at room temperature for 14 days. Salicylaldehyde-o-phenylenediimine was effective against fungi such as Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis and Fonsecaea compacta. Trichophyton mentagrophytes was inhibited at $20{\mu}g$ per ml, Trichophyton rubrum at $40{\mu}g$ per ml, Microsporum canis at $6{\mu}g$ per ml, and Fonsecaea compacta at $2{\mu}g$ per ml.