The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Studies on the Antineoplastic Components of Korean Basidiomycetes

한국산(韓國産) 담자균류(擔子菌類) 항암(抗癌) 성분(成分)에 관한 연구(硏究)

  • Kim, Byong-Kak (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Chung, Hee-Soo (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Chung, Kyung-Soo (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Yang, Moon-Sik (Department of Microbial Chemistry, College of Pharmacy, Seoul National University)
  • 김병각 (서울대학교 약학대학 미생물약품화학교실) ;
  • 정희수 (서울대학교 약학대학 미생물약품화학교실) ;
  • 정경수 (서울대학교 약학대학 미생물약품화학교실) ;
  • 양문식 (서울대학교 약학대학 미생물약품화학교실)
  • Published : 1980.09.30
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Abstract

To investigate antitumor components of Korean higher fungi, the carpophores of Ganoderma lucidum (Fr.)Karst. were collected at Gal-mae-ri in Gyeong-gi Province and extracted with 0.1N sodium hydroxide solution. The extract was purified by dialyzing through Visking tube and a dark brownish power was obtained. The antitumor activity of the fraction was tested against sarcoma 180 implanted in mice. The tumor inhibition ratio of the fraction against the tumor was 87.6% in doses of 50 mg/kg/day for the period of ten days. The tumor in five of 15 mice was completely regressed. The antitumor fraction was chemically analyzed and found to be a complex of polysaccharide and protein, from which four monosaccharides and eighteen amino acids were identified.

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