한국균학회지 (The Korean Journal of Mycology)
- 제8권2호
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- Pages.115-116
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- 1980
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- 0253-651X(pISSN)
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- 2383-5249(eISSN)
한국산(韓國産) 고등(高等) 균류(菌類)의 성분(成分) 및 배양(培養)에 관한 연구(硏究)(XXV) -구름버섯 항암성분의 면역 촉진 효과-
Studies on Constituents and Culture of the Higher Fungi of Korea(XXV) -Stimulatory Effects of Coriolus versicolor Constituents on Immune Response-
- 심미자 (서울대학교 약학대학 미생물약품화학교실)
- Shim, Mi-Ja (Department of Microbial Chemistry, College of Pharmacy, Seoul Nationl University)
- 발행 : 1980.09.30
초록
To investigate mechanism of antineoplastic activities of the protein-polysaccharide fraction of Coriolus versicolor (Fr.) Quel., the mycelium of the fungus was grown in a liquid medium and was extracted with hot water. The extract was purified and used for examining its effects upon immune response in mice. The fraction was administered at a dose of 20mg/kg/day to ICR mice for five days. After ten days the mice were immunized by sheep red blood cells. The plaque-forming cells (PFC) in their spleen were increased in the treated mice. The number of PFC in case of the protein-removed polysaccharide was lower than that of the entire protein-polysaccharide fraction of the fungus.
키워드