경구 D-PCA의 연배설에 관한 조사

A Study on the Urinary Lead Excretion after Oral D-penicillamine Administration

For the purpose of further health control, D-penicillamine was orally administered to 8 persons who were employed in lead industry and suspected lead intoxication routine industrial health examination. The does of D-penicillamine was 600 mg per day and was administered orally in every other 5 days, For the laboratory analysis 24 hours urine and 10 gm of whole blood were collected every day. The results were as follows; 1. It was found that mean urinary lead excretion per day was 446.5 g/l and 394.98 g/l, respectively during the first 5-day and the second 5-day administration with D-penicillamine. 2. Mean lead excretion per day was $130.56{\pm}66.42g/l$ after first 5-day administration and $159.28{\pm}104.44g/l$ after second 5-day administration with D-penicillamine. 3. The level of urinary lead excretion after administration increased 3 to 4 times than that before administration with D-peniciilamine. 4. Blood and urinary lead level investigated after 6 months were $44.4{\pm}10.2g/100g\;and\;72.7{\pm}29.7\;g/l$ for the eight persons.