The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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Antithyroglobulin Antibodies and Antimicrosomal Antibodies in Various Thyroid Diseases

각종(各種) 갑상선질환(甲狀腺疾患)에서의 항(抗) Thyroglobulin 항체(抗體) 및 항(抗) Microsome 항체(抗體)의 출현빈도(出現頻度)에 관(關)한 연구(硏究) (제1보)(第1報)

  • Lee, Gwon-Jun (Dept. of Int. Med. Seoul National University Hospital) ;
  • Hong, Key-Suk (Dept. of Int. Med. Seoul National University Hospital) ;
  • Choi, Kang-Won (Dept. of Int. Med.,Seoul National University Hospital) ;
  • Lee, Hong-Kyu (Dept. of Int. Med.,Seoul National University Hospital) ;
  • Koh, Chang-Soon (Dept. of Int. Med. Seoul National University Hospital) ;
  • Lee, Mun-Ho (Dept. of Int. Med. Seoul National University Hospital) ;
  • Park, Sung-Hoe (Dept. of Pathology, Seoul National University Hospital) ;
  • Chi, Je-Geun (Dept. of Pathology, Seoul National University Hospital) ;
  • Lee, Sang-Kook (Dept. of Pathology, Seoul National University Hospital)
  • 이권전 (서울의대 내과학교실) ;
  • 김병국 (서울의대 내과학교실) ;
  • 최강원 (서울의대 내과학교실) ;
  • 이홍규 (서울의대 내과학교실) ;
  • 고창순 (서울의대 내과학교실) ;
  • 이문호 (서울의대 내과학교실) ;
  • 박성회 (서울의대 병리과) ;
  • 지제근 (서울의대 병리과) ;
  • 이상국 (서울의대 병리과)
  • Published : 1979.11.20
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Abstract

The authors investigated the incidence of antithyroglobulin antibodies and antibodies and antimicrosomal antibodies measured by tanned red cell hemagglutination method in subjects suffering from various thyroid disorders. 1) In 15 normal patients, neither suffering from any thyroid diseases nor from any other autoimmune disorders, the anti thyroglobulin antibodies were all negative, but the antimicrosomal antibody was positive only in one patient (6.7%). 2) The antithyroglobulin antibodies were positive in 31.5% (34 patients) of 108 patients with various thyroid diseases, and the antimicrosomal antibodies were positive in 37.0% (40 patients). 3) of the 25 patients with Graves' diseases, 7 patients (28.0%) showed positive for the antithyroglobulin antibodies, and 9(36.0%) for the antimicrosomal antibodies. There was no definite differences in clinical and thyroid functions between the groups with positive and negative results. 4) Both antibodies were positive in 16(88.9%) and 17(94.4%) patients respectively among 18 patients with Hashimoto's thyroiditis, all of them were diagnosed histologically. 5) Three out of 35 patients with thyroid adenoma showed positive antibodies, and 3 of 16 patients with thyroid carcinoma revealed positive antibodies. 6) TRCH antibodies demonstrated negative results in 2 patients with subacute thyroiditis, but positive in one patient with idiopathic primary myxedema. 7) The number of patients with high titers ($>1:80^2$) was 16 for antithyroglobulin antibody and 62.5%(10 patients) of which was Hashimoto's thyroiditis. Thirteen(65.0) of 20 patients with high titers($>1:80^2$) for antimicrosomal antibody was Hashimoto's thyroiditis. TRCH test is a simple, sensitive method, and has high reliablity and reproducibility. The incidences and titers of antihyroglobulin antibody and antimicrosomal antibody are especially high in Hashimoto's thyroiditis.

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