약학회지 (YAKHAK HOEJI)
- 제23권2호
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- Pages.125-128
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- 1979
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
L(+)-Glutamic Acid 유도체의 합성(II)
Studies on the Synthesis of L(+)-Glutamic Acid Derivatives(II)
초록
In the formation of L(+) -glutamine from L(+) -glutamic acid-5-hydrazide, large amount of Raney-Ni was effective under normal pressure but hydrogenation or amonolysis of ester under pressure was useless. Preparation of glutamine with .alpha.-ketoglutaric acid (by way of 1, 4, 5, 6-tetrahydro-6-oxo-3-pyridazine carboxylic acid) is intersting but not so efficient in yield.
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