Archives of Pharmacal Research
- Volume 2 Issue 2
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- Pages.145-151
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- 1979
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Studies on the Constituents of Higher Fungi of Korea (XXIII)
- Kim, Byong-Kak (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
- Park, Eun-Kyue (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
- Shim, Mi-Ja (Department of Microbial Chemistry, College of Pharmacy, Seoul National University)
- Published : 1979.12.01
Abstract
The carpophores of three Korean mushrooms, Coriolus versicolor, Pleurotus ostreatus and Lentinus edodes were respectively extracted with hot water and the extracts were dialyzed through Visking tube. They were found to exert an antitumor activity against sarcoma-180 implanted in mice. Especially, the inhibition ratio of the extract of Coriolus versicolor (100 mg/ Kg.i.p) was almost 100% . But all the extracts did not affect the growth of leukemia L517Y cells in vitro. Therefore these facts indicate that the extracts appear to stimulate cell-mediated immunity.
Keywords
- Basidiomycetes-the family Poly-poraceae-Coriolus versicolor;
- Pleurotus ostreatus;
- and Lentinus edodes;
- Antineoplastic components-a protein-bound polysaccharide;
- Antitumor activity against asrcoma-180 inplanted in mice.