Archives of Pharmacal Research
- Volume 2 Issue 2
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- Pages.85-88
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- 1979
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Interfacial and Free Energy Effects in Aqueous Amide Cosolvents
- Lee, Chi-Ho (College of Pharmacy, Busan National Univetsity) ;
- Richard E. Lindstrom (The University of Connecticut)
- Published : 1979.12.01
Abstract
Data on the solubility of p-hydroxy-benzoate in amide-water cosolvent system and surface tension of the binary amide-water cosolvents are analyzed in terms of the possible mechanism for cosolvency. The results of the study suggest that strong partitioning of the alkylated amides to the ester surface, thus reducing the hydrophobic interface within the system, nay account for much of the cosolvency phenomena observed in these systems.
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