Journal of Pharmaceutical Investigation
- 제9권3호
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- Pages.1-8
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- 1979
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Isonicotinic Acid Hydrazid (INH)의 불활성화(不活性化)에 관한 연구(硏究)
The Inactivation of Isonicotinic Acid Hydrazid (INH)
초록
The main route of metabolism of isonicotinic acid hydrazid (INH) in man is its conjugation with acetyl coenzyme A to form acetyl-INH. The reaction is catalyzed by an N-acetyl transferase in the liver. The acetylated drug can be excreted by the kidney more efficiently than INH, and the biological half-life of the drug in the body depends upon how rapidly the drug can be acetylated. This report measured the concentration of INH in the blood of 147 individuals 6 hours after they received a standard dose (9.8mg/kg) and plotted the data as a frequeney distribution hiotogram. There was bimodality, with a mean for one subpopulation at approximately
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