Korean Journal of Pharmacognosy (생약학회지)
- Volume 10 Issue 2
- /
- Pages.73-77
- /
- 1979
- /
- 0253-3073(pISSN)
- /
- 2288-9299(eISSN)
Antiinflammatory Action of Phytolaccosides
Phytolaccosides의 소염작용(消炎作用)
-
Shin, Kuk-Hyun
(Natural Products Research Institute, Seoul National University)
;
- Woo, Won-Sick (Natural Products Research Institute, Seoul National University) ;
- Lee, Chung-Kyu (Natural Products Research Institute, Seoul National University)
- Published : 1979.06.15
Abstract
Antiinflammatory action of phytolaccosides B and E isolated from the roots of Phytolacca americana was investigated and compared with that of aescin. Phytolaccoside B, when it was administered intravenously, exerted a potent inhibitory effect on the transudation caused by absorptive sponge pellet implanted s.c. in rats and on carrageenin induced edema in rats. Phytolaccoside E showed a weaker action than Phytolaccoside B did. Hemolytic potency of the saponins was decreased in the order of aescin, phytolaccosides B and E showing a same tendency as in antiinflammatory action. The experimental result suggests that the mode of action of phytolaccosides is the same as that of aescin.
Keywords