Effects of Hexestrol Administration on Serum Components in Hypophysectomized Female Rats

Hexestrol의 투여(投與)가 하수체척출(下垂體剔出) 암흰쥐의 혈청성분(血淸成分)에 미치는 영향(影響)

This study was made to investigate whether there would be any direct relationship between ovary and serum components without the control mechanism from the hypophysis. After the administration of hexestrol (6.0mg/head) to the hypophysectomized female rats, the serum components such as total lipid, cholesterol, total protein, non-protein nitrogen, Na, Cl, and K were measured for 8 weeks after treatments. The results were obtained as follows; 1. The contents of total lipid and cholesterol for the treatment groups were increased significantly as compared with the control group at the 2nd week and there on. However, there were no ditferences between the hypophysectomized and the hexestrol treated-hypophysectomized groups. 2. The contents of total protein and non-protein nitrogen for the hypophysectomized and the hexestrol treated-hypophysectomized groups were gradually increased as the time passed in comparison with the control group. The differences between the control group and the treatment groups were significant at the 4th week and there on, and the differences between the hypophysectomized and the hexestrol treated-hypophysectomized groups were insignificant, but the hypophysectomized group had slightly high value. 3. For the contents of Na, Cl, and K, there was not any unique change but only a slight flactuation in its level, and the differences were thus statistically insignificant in all cases. 4. In the hypophysectomized famale rats, administration of hexestrol had a litlle effect on the metabolism of protein, but on the other hand, no effect of those of lipid and minerals.

난소(卵巢)의 분필기능(分泌機能)이 하수체(下垂體)의 조절기능(調節機能)없이 혈청성분(血淸成分)에 직접적(直接的)인 영향(影響)을 미치는가를 구명(究明)하기 위하여 암흰쥐에서 하수체(下垂體)를 척출(剔出)하고 마리당 6.0mg씩의 hexestrol을 투여(投與)한 후 혈청(血淸)중의 총지방(總脂肪), Cholesterol, 총단백질(總蛋白質), Non-protein nitrogen, Na, Cl 및 K의 변화를 처리(處理) 8주후(週後)까지 조사(調査)하여 비교검토(比較檢討)한 바 다음과 같은 결론(結論)을 얻었다. 1. 총지방(總脂肪)과 cholesterol의 양(量)은 대조군(對照群)에 비하면 2주후(週後)부터 유의성(有意性)이 인정(認定)되는 증가(增加)를 하였는데, 하수체척출군(下垂體剔出群)과 하수체척출후(下垂體剔出後) hexestrol 투여군간(投與群間)에는 유의성(有意性)이 인정9認定)되지 않았다. 2. 총단백질(總蛋白質)과 Non-protein nitrogen의 함량변화(變化)는 동일(同一)한 경향(傾向)으로서 시간(時間)이 경과(經過)함에 따라 점증(漸增)하였는데, 대조군(對照群)에 대하여 처리(處理) 4주후(週後)부터 유의성(有意性)이 인정(認定)되었고, 하수체척출군(下垂體剔出群)과 하수체척출후(下垂體剔出後) hexestrol 투여군간(投與群間)에는 유의성(有意性)은 인정(認定)되지 않았으나 하수체척출군(下垂體剔出群)에서 높은 값을 나타냈다. 3. Na, Cl 및 K의 함량(含量)은 일정(一定)한 변화경향(變化傾向)없이 근소하게 증감(增減)하여 전(全) 실험기간(實驗期間)에 걸쳐서 비교군간(比較群間)에 유의성(有意性)을 인정(認定)할 수 없었다. 4. 하수체척출(下垂體剔出) 암흰쥐에 있어서 hexestrol의 투여(投與)는 단백질대사(蛋白質代謝)에는 약간의 영향(影響)을 미치나, 지질(脂質) 및 무기물(無機物)의 대사(代謝)에는 영향(影響)을 미치지 못한다고 생각된다.