YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Elimination Reaction of $\alpha$-Diethaylaminoacetophenone in the Formation of Hydantoin Derivatives

히단토인 유도체 형성에 있어서 $\alpha$-Diethaylaminoacetophenone의 탈이반응

  • Published : 1978.12.01
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Abstract

It is known that hydantoin derivative can be synthesized according to the method of Bucherer-Bergs, which employs the interaction of the carbonyl compounds with potassium cyanide and ammonium carbonate in dilute alcohol solution. In a converting study of .alpha.-dietylaminoacetophenone with KCN and ($NH_{4})_{2}CO_{3}$ to hydantoin, the attempted 5-diethylaminomethyl-5-phenylhydantoin was not formed. In this reaction diethylaminomethly group was unexpectedly eliminated and 5-phenylhydantoin was obtained, instead of the anticipated compound.

Keywords

References

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