Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
권호 표지

The Study on Conformation and Biological Activity for the Drug Design. Phenethylamine Derivatives as the Sympathomimetics

새로운 의약품의 개발을 위한 의약품의 분자구조와 약리효과에 관한 연구. 교감신경모방약으로 작용하는 Phenethylamine 유도체들에 관하여

  • Kim, Ui Rak (Department of Chemistry, Catholic Medical College)
  • Published : 1977.08.30
Download PDF
⟨ Previous Next ⟩

Abstract

We applied the EHT method to 23 kinds of adrenergic agents, sympathomimetics, which were derived from phenethylamine by introducing hydroxy and methyl group to benzene ring, ${\alpha}-\;or\;{\beta}$-position and nitrogen of ethylamine. We have stated and discussed theoretically the relationship between their structural characteristics and biological activities by compairing with the calculated values.

교감신경 흥분성 amine류의 분자구조와 약리효과 간의 관계를 설명하기 위하여 phenethylamine에서 benzene 고리와 ethylamine의 ${\alpha},{\beta}$ 위치와 amine의 질소에 hydroxy기와 methyl기 등을 도입한 23종의 약품에 대한 분자 특성을 EHT법으로 계산하여 검토하였다.

Keywords

References

  1. J. Korean Chem. Soc. v.16 Y. B. Chae;U. I. Cho;M. S. Jhon
  2. J. Chem. Phys v.39 R. Hoffmann
  3. Tables of Interatomic Distances and Configuration in Molecules and Ions no.11;18 L. E. Sutton(ed.)
  4. J. Chem. Phys. v.38 E. Clementi;D. L. Raimondi
  5. J. Amer. Chem. Soc. v.84 J. Hinze;H. H. Jaffe
  6. J. Pharmacology and Experimental therapeutics v.174 L. B. Kier;E. B. Truitt, Jr.
  7. Amer. J. Physiol. v.154 R. P., Ahlquist
  8. Arch. Intern. Pharm acology v.139 R. P., Ahlquist
  9. J. Pharm. Sci. v.55 R. P., Ahlquist
  10. J. Physiol. v.1 J. N. Langley
  11. Arzeneimittelforsch v.7 H. G. Mautner
  12. Handbuch der Experimentellen Pharmakologie v.4 General Pharmacology A. J. Clark:Heffter, A.(ed.)
  13. Science v.130 G. Karreman, I. Isenberg:A. Szent-Gyorgyi
  14. Molecular Orbital Theory in Drug Research L. B. Kier
  15. J. Pharm. Pharmacol. v.21 L. B. Kier
  16. Aspect de la Chimie Quantique Contemporaine L. B. Kier:R. Daudel(ed.):A. Pullman(ed.)
  17. Mol. Pharmacol. v.7 J. M. George:L. B. Kier:J. M. Hoyland
  18. Arch. Exp. Pathol. Pharmakol. (Naunyn-Schmiedebergs) v.219 A. M. Lands:M. L.Tainter
  19. Mil. Med. Suppl. v.131 F. E. Hahn:R. L. O'Brien:J. Ciak:J. L. Allison:J. G. Olerick
  20. J. Amer. Chem. Soc. v.74 R. S. Mulliken