Alloxan Diabetes 동물(動物)에서의 Sulfisoxazole의 흡수(吸收)와 배설(排泄)에 관(關)한 연구(硏究)

The Studies on the Absorption and Excrection of Sulfisoxazole from Alloxan Diabetes States

Absorption of sulfisoxazole after oral administration was significantly increased by small dose(60mg/kg) of alloxan but not increased significantly by large dose (160mg/kg) of alloxan from that of normal rabbits. Pretreatment with alloxan did not give any effect on clearance of sulfisoxazole. As the results, It could come to conclusion that in creased absorption of the sulfisoxazole administered small dose of the alloxan was influenced by transport of intestinal membrane or intestinal enzyme activation or increase of intestinal absorption function.