Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Photochemical Synthesis of Phenylglycine

페닐글리신의 광화학적 합성

  • Sang Chul Shim (Department of Chemical Sciences, The Korea Advanced Institute of Science) ;
  • Chung Hak Lee (Department of Chemical Sciences, The Korea Advanced Institute of Science)
  • 심상철 (한국과학원 화학 및 화학공학과) ;
  • 이정학 (한국과학원 화학 및 화학공학과)
  • Published : 1976.06.30
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Abstract

Phenylacetic acid is chlorinated photochemically in carbon disulfide and carbon tetrachloride solvents to obtain ${\alpha}$-chlorophenylacetic acid in $43{\%}$ yield (after separation and purification). The amination of ${\alpha}$-chlorophenylacetic acid yielded the desired dl-phenylglycine in $16\sim27{\%}$ yield depending on the solvent used. Sensitized photophenylation of glycine is also attempted utilizing benzoylperoxide as a phenyl radical source in benzene or acetone solvent.

페닐아세트산을 이황화탄소와 사염화탄소 용매에서 광염소화시켜 $43{\%}$ 수득률로 ${\alpha}$-클로로페닐아세트산을 얻었다. 여기에 암모니아를 가하여 가열해 주었더니 $16\sim27{\%}$수득률로 페닐글리신이 합성되었다. 또한 글리신유도체에 광페닐화 반응을 아세톤, 벤조페논 증감제와 benzoylperoxide를 써서 시도하였다.

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