Journal of Pharmaceutical Investigation
- 제6권3호
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- Pages.48-57
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- 1976
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Dissolution Characteristics of Hydrophobic Drug-Soluble Carrier Coprecipitate (I)-Enhanced Dissolution Rates of Furosemide from Furosemide Polymer Coprecipitates-
- Shin, Sang-Chull (College of Pharmacy, Seoul National University) ;
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Lee, Min-Hwa
(College of Pharmacy, Seoul National University) ;
- Woo, Jong-Hak (College of Pharmacy, Seoul National University)
- 발행 : 1976.09.20
초록
An enhancement in the dissolution rate of the drug should facilitate its GI absorption if the absorption process is dissolution rate limited. One of the need for the techniques that can potentially enhance the dissolution rate and extent of absorption of hydrophobic drugs is the formation of coprecipitates with pharmacologically inert, polymeric materials. The physicochemical modification offers the advantage of possibly enabling one to administer the drug orally in a form from which it is most available for GI absorption. Several
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