Journal of Pharmaceutical Investigation
- Volume 6 Issue 1
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- Pages.26-32
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- 1976
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
A Study on the Properties of Dicalcium Phosphate Dihydrate According to the Manufacturing Condition
제이인산(第二燐酸)칼슘의 제조조건(製造條件)에 따른 성상(性狀) 연구(硏究)
- Lah, Woon-Lyong (College of Pharmacy, Seoul National University) ;
- An, Kyung-Ran (College of Pharmacy, Seoul National University) ;
- Han, Kwan-Sup (National Health Institute) ;
- Lee, Gye-Joo (National Health Institute)
- Published : 1976.03.20
Abstract
Dicalcium phosphate dihydrate (DCPD) is the most widely-used dentifrice abrasive in non-therapeutic tooth-paste requiring, low abrasive level, high stability and excellent compatibility with other formulation ingredients. One of the difficulties encountered in the use of this material in tooth-paste is that unless storage of the product is maintained at a relative low temperature there is a distinct tendency to lose water of crystallization. Another difficulty which has been encountered is that there is a tendency for the product to become lumpy. Various means have been proposed for increasing the stability and overcoming the lumping tendency, most of which means comprise the addition of stabilizing agent. But there is not any report about the relationships between the mechanism of dehydration, physical properties, structure and manufacturing condition. In this experiment, DCPD were manufactured by methods of Moss' patent, its two varied and J.P.VIII, these were studied by means of stability test, IR spectra, and DTA. According to the manufacturing conditions, DCPD has different physical properties and structures, i. e., monoclinic system of low drying temperature, triclinic system of high drying temperature. Dehydration of DCPD may be supposed one step debydration at about
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