Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Selective Reduction of Keto Esters with Zinc Borohydride

수소화붕소 아연에 의한 케토에스데르의 선택환원

  • Nung Min Yoon (Department of Chemistry, College of Science and Engineering Sogang University) ;
  • Jahyo Kang (Department of Chemistry, College of Science and Engineering Sogang University)
  • 윤능민 (서강대학교 이공대학 화학과) ;
  • 강재효 (서강대학교 이공대학 화학과)
  • Published : 1975.10.30
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Abstract

Selective reduction of carbonyl group with zinc borohydride in the presence of ester functional group was demonstrated with seven representative keto esters. Either hydroxy esters or lactones were obtained in good yields; ethyl 6-hydroxyheptanoate ($83.0{\%}$), ethyl 2,6-dimethyl-4-hydroxy-2-cyclohexenecarboxylate ($82.3{\%}$), ethyl p-(${\alpha}$-hydroxyethyl)-phenylacetate ($78.9 {\%}$), 4-phenylbutyrolactone ($70.2{\%}$), and 3-phenylphthalide ($92.4{\%}$) were obtained from the corresponding keto esters.

대표적 케토에스테르를 수소화붕소아연으로 선택환원하여 해당하는 히드록시에스테르 또는 락톤을 좋은 수득률로 합성하였다.

Keywords

References

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