The Korean Journal of Pharmacology (대한약리학회지)
- Volume 11 Issue 2
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- Pages.19-27
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- 1975
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- 0377-9459(pISSN)
Experimental Studies on the Cardiovascular Effects of Haloperidol in Cat and Rabbit
Haloperidol 이 심혈관계에 미치는 영향
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Ahn, Young-Soo
(Department of Pharmacology, Yonsei University College of Medicine)
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안영수
(연세대학교 의과대학 약리학교실)
- Published : 1975.12.30
Abstract
Haloperidol, a butyrophenone, was synthetized by Janssen and introduced for the treatment of psychosis. Although structurally different from the phenothiazines, the butyrophenones share many of their pharmacological properties, such as inhibition of conditioned avoidance response, blocking effect of amphetamine reaction, producing catalepsy, antishock effect and protection against the lethal effects of catecholalmines. Chlorpromazine can lower the arterial blood pressure through its adrenergic blocking activity, its direct effect in relaxing vascular smooth muscle, its direct effect in depressing the myocardium and its action in a complex manner on the central nervous system. In the case of haloperidol, however, was not clarified the mechanism of lowering the blood pressure. The present paper describes the effects of haloperidol on cardiovascular system to investigate the mechanisms of its actions on the arterial blood pressure. The results are followings; 1. In anesthetized cats, intravenous administration of haloperidol and chlorpromazine in the dose of 0.1mg/kg produced a slight decrease in the blood pressure, which followed by complete recovery within
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