The Korean Journal of Pharmacology (대한약리학회지)
- Volume 11 Issue 2
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- Pages.1-8
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- 1975
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- 0377-9459(pISSN)
Effects of Testosterone on Carbonic Anhydrase Inhibiting Action of Acetazolamide
Acetazolamide 의 Carbonic Anhydrase 활성 억제 작용에 대한 Testosterone 의 영향
- Chang, Dong-Won (Department of Pharmacology, Catholic Medical College) ;
- Lee, Sang-Bok (Department of Pharmacology, Catholic Medical College) ;
- Cho, Kyu-Chul (Department of Pharmacology, Catholic Medical College)
- Published : 1975.12.30
Abstract
This study was carried out to observe the effect of testosterone on carbonic anhydrase inhibiting action of acetazolamide. Carbonic anhydrase activities in the kidneys of mice were measured by Philpot and Philpot method(1936) at 30, 90 and 150 minutes after intravenous administration of saline(0.5 ml/10 g) or acetazolamide (0.25 mg/10 g) in mice pretreated with testosterone (0.1 mg/10 g). The changes in volume and pH of urine as well as those in urinary electrolytes, such as
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