The Journal of the Korean dental association (대한치과의사협회지)
- Volume 12 Issue 3
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- Pages.155-158
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- 1974
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- 0376-4672(pISSN)
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- 2713-7961(eISSN)
불소가 발육중인 백서악하선의 Catecholamine에 미치는 영향
Abstract
Catecholamine levels were determined in the submandibular glands of new born rats treated with physiologieal saline solution or large doses of sodium fluoride (10mg/kg) for verying periods of time. In control group, catecholamine levels were gradually increased from fifth day of life until twenty-fifth day of life. When fluoride treatment was started on the fifth day after birth and continued daily to the thirty-fifthday of life, decreased catecholamine levels were obsrved on the fifth, through all experiments, and thirth-fifth day. Daily fluoride treatment from the fifteenth through the thirty-fifth day after birth induced the decreased catecholamine levels which were higher than the levels in submandibular glands of rats treated from the fifth day to the thirty-fifth day after birth with NaF. These experiments suggest that fluoride may be affecting catecholamine biosynthetic mechanisms which were duveloping during the fifteenth to twenty-fifth day of life.
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