Effect of Sodium Phenobarbitone and β-Diethylaminoethyl Diphenylpropyl Acetate(SKF 525 A) on the Liver Lesions Caused by a Single Intraperitoneal Dose of Ngaione in the Rat

Sodium Phenobarbitone 및 β-Diethylaminoethyl Diphenylpropyl Acetate (SKF 525 A)가 Ngaione에 중독(中毒)된 흰쥐의 간장병변(肝臟病變)에 미치는 영향(影響)

Ngaione isolated from leaves of Myoporum deserti was dosed to the phenbarbitone and SKF 525 A pretreated male rat and studied the liver lesions. The results obtained were summarized as follows: 1. The liver lesions are mostly zonally distributed and involved the midzonal parenchyma chiefly with tendence to include also associated periportal hepatocytes. 2. The histopathology of liver due to ngaione after phenoharbitone pretreatment is characterized by the consistent pretence of degeneration and necrosis of the periportal parenchyma. 3. Zonal liver lesions caused by ngaione in the SKF 525 A pretreated rat are consistently periacinar in location.