약학회지 (YAKHAK HOEJI)
- 제18권4호
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- Pages.249-254
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- 1974
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
2-Aryl-3-(5-nitro-2-furyl) acrylamide류의 합성과 항균작용에 관한 연구
Studies on the Synthesis and Antimicrobial Activity of 2-Aryl-3-(5-nitro-2-furyl) acrylamides
초록
Eighteen 2-aryl-3-(5-nitro-2-furyl) acrylamides were synthesized as antimicrobial agent, by the condensation of 2-(p-sulbstituted phenyl)-3-(5-nitro-2-furyl) acryloyl chloride with amino component, such as sulfisozxazole, sulfamethoxypyridazine and sulfadimethoxine. All compounds showed fair bacteriostatic activity against staphylococcus aureus 6538p, Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae. 2-(p-Hydroxyphenyl)-and 2-(p-acetoxyphenyl) compounds also showed antimicrobial activity against Saccharomyces cerevisiae 396 and Aspergillus oryzae.
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