Syntheses and antimicrobial and antitumor activities of isatin derivatives

  • Chough, Yun-Sung (Department of Pharmacodynamics,College of Pharmacy, Seoul National University) ;
  • Kang, Kun-Il (Department of Pharmacodynamics,College of Pharmacy, Seoul National University)
  • Published : 1973.09.01

Abstract

Eight isatin N-Mannich bases were synthesized and tested their antimicrobial and antitumor activities. N-Piperidinomethylisatin-(N-cyclohexyl)-thiosemicarbazone is active against St. aureus at 10${\mu}$g/disk and isatin thiosemicarbazone against P. chrysogenum at 10${\mu}$g disk.

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