Studies on the Synthesis of Antineoplastic Agents. VI. Synthesis and Antineoplastic Activity of 2,4-Dihydroxy-5-nitropropiophenone Derivatives.

제암성물질의 합성에 관한 연구 VI 2,4-Dihydroxy-5-nitropropiophenone 유도체의 합성 및 항종양시험

Seven ${\beta}$-substituted-2,4-dihydroxy-5-nitropropiophenones were synthesized as potential antineoplastic agents, and subjected to the screening test of survival effect and cell decrease effect. Of the sunthesized compounds, ${\beta}$-(1-methyl-1-hydroxymlethy) ethylamino-2, 4-dihydrocy-5-nitropropiophenone and ${\beta}$(1,1-dihydorxymethyl) ethylamino-2,4-dihydroxy-5-dihyropropiophenone and ${\beta}$-(1,1-dihydroxymethyl) propylamino-2,4-dihydroxy-5-nitropropiophenone were found to be active against both Ehrlich ascites carcinoma and Sarcoma 180.