대한약리학회지 (The Korean Journal of Pharmacology)
- 제9권2호
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- Pages.17-27
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- 1973
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- 0377-9459(pISSN)
흰쥐의 위(胃).십이지장(十二指腸) 동시관류표본(同時灌流標本)에 대(對)한 Caerulein의 작용(作用)
Effect of Caerulein on the Pancreatic and Gastric Secretion in Rats Studied by Means of Duodenal and Gastric Perfusion
- Cho, T.S. (Department of Pharmacology, Yonsei University College of Medicine) ;
- Shin, C.J. (Department of Pharmacology, Yonsei University College of Medicine) ;
- Lee, B.H. (Department of Pharmacology, Yonsei University College of Medicine) ;
- Hong, S.S. (Department of Pharmacology, Yonsei University College of Medicine)
- 발행 : 1973.12.30
초록
Modifying the technique described by Schmidt, et al. (1972) the duodenum and stomach of female rats were perfused separately and contiunously with saline solution under urethane anesthesia. Secretory response of caerulein (Prof. V. Erspamer, F.I. 6934 Caerulein, Farmitalia, Italia), a gastrin or CCK-PZ like peptide, on acid, pepsin, bicarbonate and amylase were studied with and without simultaneous administration of secretin, CCK-PZ or other agents known secretory suppressives. A significant increase of acid, pepsin and amylase output was induced by intravenous infusion of caerulein. The response of acid secretion by caerulein in doses of 140 ng/100g/hr was equivalent to the response of histamine in the doses of
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