대한약리학회지 (The Korean Journal of Pharmacology)

대한약리학회 (The Korean Society of Pharmacology)
권호 표지

Pentazocine의 가토혈당(家兎血糖), 혈청(血淸) Transaminase 및 Alkaline Phosphatase 활성도(活性度)에 대(對)한 작용(作用)

The Action of Pentazocine on the Blood Sugar Level, Serum Transaminase and Alkaline Phosphatase Activities in Rabbits

  • 박정인 (고려대학교 의과대학 약리학교실) ;
  • 이운구 (고려대학교 의과대학 약리학교실) ;
  • 홍권희 (고려대학교 의과대학 약리학교실) ;
  • 김양순 (고려대학교 의과대학 약리학교실)
  • Park, Jung-In (Department of Pharmacology, College of Medicine, Korea University) ;
  • Lee, Woon-Ku (Department of Pharmacology, College of Medicine, Korea University) ;
  • Hong, Kwon-Hee (Department of Pharmacology, College of Medicine, Korea University) ;
  • Kim, Yang-Soon (Department of Pharmacology, College of Medicine, Korea University)
  • 발행 : 1973.06.30
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초록

A benzomorphan derivative, pentazocine has both opioid agonistic actions and weak narcotic antagonistic activity. In this paper, authors attempted to study the dose response of pentazocine on the blood sugar level, serum transaminase and alkaline phosphatase activity in rabbits. Eighteen rabbits were devided into 3 groups, and each group were injected with pentazocine 5mg, 15mg, and 30mg/kg respectively. And metabolic effects were investigated measuring the change of blood sugar contents, serum transaminase (S-GOT, S-GPT) activities and alkaline phosphatase activities in rabbits. The results were obtained as follows; 1. Pentazocine significantly increased the blood sugar content in rabbits. 2. Pentazocine significantly increased the serum GOT activity but in the serum GPT activity, it significantly increased in large dose. 3. Pentazocine significantly increased serum alkaline phosphatase activity.

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