The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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The Clinical Study on the Effects of $Tapazole^{(R)}\;upon\;^{131}I$ Uptake in Hyperthyroidism

갑상선(甲狀腺) 기능항진증(機能亢進症)에서 $Tapazole^{(R)}$이 $^{131}I$섭취율(攝取率)에 미치는 영향(影響)에 관(關)한 임상적(臨床的) 고찰(考察)

  • Ro, Heung-Kyu (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Lee, Jung-Sang (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Koh, Chang-Soon (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Lee, Mun-Ho (Department of Internal Medicine, College of Medicine, Seoul National University)
  • 노흥규 (서울대학교 의과대학 내과학교실) ;
  • 이정상 (서울대학교 의과대학 내과학교실) ;
  • 고창순 (서울대학교 의과대학 내과학교실) ;
  • 이문호 (서울대학교 의과대학 내과학교실)
  • Published : 1969.11.25
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Abstract

The differences in the change of the uptake rate of radioactive iodine ($^{131}I$) in the thyroid gland after $Tapazole^{(R)}$ administration before $^{131}I$ treatment were analysed in 137 patients who were diagnosed as diffuse toxic goiter in the Radioisotope Clinic and Laboratory, Seoul National University Hospital since Jan. 1967 to July, 1969. The uptake rate of the therapeutic dose of $^{131}I$ was changed diffusely compared with that of the trace dose in the patients who had no $Tapazole^{(R)}$ administration before $^{131}I$ treatment. In those patients who had $Tapazole^{(R)}$ more than 20 mg/day for more than one week before $^{131}I$ treatment, the uptake rate was decreased significantly. When the patients discontinued the administration of $Tapazole^{(R)}$ 7 days prior to $^{131}I$ treatment, the uptake rate was increased in all cases.

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