Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Reaction of Nitrous Acid on 5-Aminopyrimidine (Ⅳ) The Synthesis of 5-Cyano-and 5-Carboxypyrimidines

5-Aminopyrimidine에 대한 아질산의 반응 (Ⅳ) 5-Cyano 및 5-CarboxyPyrimidine 유도체의 합성

  • Chang Sae Hee (Department of Chemistry, College of Liberal Arts and Science, Seoul National University) ;
  • Kim Jae Soon (Separtment of Chemistry, Sogn Sim College for Women) ;
  • Huh Tae Soung (Separtment of Chemistry, Sogn Sim College for Women)
  • 장세희 (서울대학교 문리과대학 화학과) ;
  • 김재순 (성심여자대학 화학과) ;
  • 허태성 (성심여자대학 화학과)
  • Published : 19690600
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Abstract

5-Cyanopyrimidine derivatives were synthesized starting from 5-aminopyrimidine derivatives through the extended Sandmeyer reaction, and then these compounds were hydrolyzed to obtain pyrimidine-5-carboxylic acids. According to this procedure, 5-cyanopyrimidine derivatives and pyrimidine-5-carboxylic acid derivatives have been prepared in 62% and 65% yields, respectively, without any difficulties in removing impurities.

5-Cyanopyrimidine 유도체를 5-Aminopyrimidine 유도체로부터 Sandmeyer반응에 의하여 합성하고 이 화합물들을 가수분해하여 Pyrimidine-5-carbolylic acid 을 합성하였다. 이 방법에 의하면 불순물 제거의 어려움 없이 5-Cyanopyrimidine유도체와 Pyrimidine-5-carboxylic acid유도체를 62%와 65%의 수율로 합성할 수 있었다.

Keywords

References

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