The Korean Journal of Zoology (한국동물학회지)
- Volume 12 Issue 4
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- Pages.114-122
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- 1969
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- 0440-2510(pISSN)
Radioprotective Effect of Methylene Blue: 2. Electron Microscopy of the Effect of Methylene Blue on the Liver and Heart of Rats following Gamma-Irradiation
Methylene Blue의 방사선방어결과 2. Methylene Blue가 $\gamma$ 선에 조사한 흰줘의 간 및 심장조직에 미치는 전자현미경적 연구
- Sang Yul Nam (Dept. of Biology, Kyung Hee University) ;
- Seung Han Chang (Dept. of Biology, Kyung Hee University)
- Published : 1969.12.01
Abstract
Electron microscopic examination of the liver and heart tissues of methylene blue-treated rats before gamma-irradiation was observed in this study. 1. It was observed severe alteration and degeneration of organelles: accumulation of glycogen particles, severe swollen mitochondria, and broken endoplasmic reticulum in liver tissue of saline-treated rat(control) opposed by emthylene blue-treated rat at 64 and 212 hours following gamma-irradiation. 2. Heart muscles of both methylene blue-treated and saline-treated rats showed no significant alterations, but it was observed that slightly elongated mitochondria with broken cristae and some of vacuoles as well as increased glycogen particles in sarcoplasmic reticulum at 212 hours following gamma-irradiation. 3. It may be considered that methylene blue greatly reduces the sensitivities of rats to gamma-irradiation.
成體 albino 흰쥐를 實驗群과 對照群으로 나누어 對照群에는 0.9% 生理食鹽水를, 實驗群에는 methylene blue(38mg/kg, pH 7.4)를 各各 腹腔에 注射한 後 約 30 分後에 總線量 360 rads의
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