YAKHAK HOEJI (약학회지)
- Volume 13 Issue 1
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- Pages.43-46
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- 1969
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Studies on the synthesis and antitubercular activity of acyl derivatives of isonicotinic acid hydrazide
Isonicotinic acid hydrazide의 acyl 유도체 합성및 항균작용에 관한 연구
Abstract
Five new acyl derivatives of isonicotinic acid hydrazide such as N-(2,4-dichlorophenoxyacetyl)-isoniotinic acid hydrazide (I), N-(p-nitrobenzoyl)-isonicotinic acid hydrazide (II), N-benzoylisonicotinic acid hydrazide (III), N-furoylisonicotinic acid hydrazide (IV) and N-(p-aminobenzoyl)-isonicotinic acid hydrazide (V) were synthesized. They were obtained by the action of 2,4-dichlorophenylacetyl chloride, p-nitrobenzoyl chloride, benzoyl chloride, furoyl chloride and p-aminobenzoyl chloride with isonicotinic acid hydrazide in pyridine solution. Evaluated for their in vitro antitubercular activity against Mycobaterium tuberculosis H
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