참고문헌
- Private communication G. Gleason
- Medical symposium No. 9 R. S. Yallow;V. M. Hunter
- Proceeding of the symposium on nuclearmedicine
- J. of Nucl. Sci. Korea v.7 Y. S. Kim
- This Journal v.11 Y. S. Kim;C. D. Kim
대한화학회지 (Journal of the Korean Chemical Society)
- 제12권1호
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- Pages.35-38
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- 1968
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- 1017-2548(pISSN)
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- 2234-8530(eISSN)
放射性 요오드化 反應 (第 II 報) 有機容媒 中에서의 各種 芳香誘導體의 低溫 요오드化 反應
Radio iodination (II) Radio iodination of various aromatic derivatives in organic solvent at low temperature
- Kim, You-Sun (Chemistry Division, Atomic Energy Research Institute) ;
- Kim, Chong-Doo (Chemistry Division, Atomic Energy Research Institute)
- 발행 : 19680300
초록
Radio iodination of various aromatic derivatives (aniline, toluene, iodobenzene, acetanilide, benzene, benzoic acid) were achieved at low temperature by a chloroamine-T procedures in presence of polar solvent(dioxane). Organic base (piperidine) was used as the catalyst. Iodine replacement reaction had occured on the aromatic or alicyclic ring by this reaction, and the kind and ratio of iodinated products were proved to be different from those of usual iodide reaction in organic solvent at low temperature. The reactivity of various aromatic or alicyclic compounds towards the present iodination system was evaluated and the scope and limitation of the present procedures in the preparation of radio pharmaceuticals were discussed.
키워드