참고문헌
- Private communication G. Gleason
- Medical symposium No. 9 R. S. Yallow;V. M. Hunter
- Proceeding of the symposium on nuclearmedicine
- J. of Nucl. Sci. Korea v.7 Y. S. Kim
- This Journal v.11 Y. S. Kim;C. D. Kim
Radio iodination of various aromatic derivatives (aniline, toluene, iodobenzene, acetanilide, benzene, benzoic acid) were achieved at low temperature by a chloroamine-T procedures in presence of polar solvent(dioxane). Organic base (piperidine) was used as the catalyst. Iodine replacement reaction had occured on the aromatic or alicyclic ring by this reaction, and the kind and ratio of iodinated products were proved to be different from those of usual iodide reaction in organic solvent at low temperature. The reactivity of various aromatic or alicyclic compounds towards the present iodination system was evaluated and the scope and limitation of the present procedures in the preparation of radio pharmaceuticals were discussed.