A procedure, which is effective enough to label various compounds at low temperature by radioactive iodine, was investigated. The chloramine-T procedure was mostly effective for labelling various protein, amino acids, hormones, and organic compounds by iodine, and the procedure was able to afford both high specific activity and high radiochemical yield. However, the procedure was ineffective for labelling unsaturated compounds or other organic compounds which has not active aromatic nucleus of reactive character. The radiochemical yield of the procedure was generally averaged from 100% to 60%. The reactivity of the aromatic part of the organic compound towards this reagent was correspond to that of an electrophillic reagent. The procedures were described and the reaction path was considered.
放射性 沃化反應 中 分解하기 쉬운 化合物의 沃化反應으로 有用한 低溫沃化反應에 關하여 硏究하였다. Chloroamine-T를 利用한 沃化反應은 低溫에서 높은 收率로 放射性 沃化反應을 進行시킬 수 있었으며, 活性化된 芳香核이 있는 또는 이에 類似한 아미노酸, 蛋白質化合物, 各 種 Phenol類의 沃化가 不可能하였으나 二重結合化合物 및 一般化合物엔 큰 效果가 없었다. 反應收率은