Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Reaction of Nitrous Acid on 5-Aminopyrimidines [III] Sandmeyer Reaction of Diazotizated 5-Amino-6-Methyluracil

Aminopyrimidine 유도체에 대한 아질산의 작용 [III] Diazotizated 5-Amino-6-Methyluracil에 대한 Sandmeyer 반응

  • Chang, Sae-Hee (Dept. of Chemistry, College of Liberal Arts and Sciences Seoul National University) ;
  • Hahn, Bo-Sup (Dept. of Chemistry, College of Liberal Arts and Sciences Seoul National University) ;
  • Kim, In-Kyu (Dept. of Chemistry, College of Liberal Arts and Sciences Seoul National University) ;
  • Oh, Sea-Hwa (Dept. of Chemistry, College of Liberal Arts and Sciences Seoul National University)
  • 장세희 (서울대학교 문리과대학 화학과) ;
  • 한보섭 (서울대학교 문리과대학 화학과) ;
  • 김인규 (서울대학교 문리과대학 화학과) ;
  • 오세화 (서울대학교 문리과대학 화학과)
  • Published : 19660600
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Abstract

A new conventional method for the preparation of 5-iodo, chloro-, and bromo-6-methyluracil by Sandmeyer reaction was described. According to this procedure, 5-halo-6-methyluracils have been prepared in high yields (up to 70%) without any difficulties to obtain highly pure products. No appreciable competing reaction was observed.

Sandmeyer 반응으로 5-Amino-6-methyluracil로 부터 5-iodo-, 5-chloro- 및 5-bromo-6-methyluracil을 간편하게 합성하는 방법을 새로히 마련하였다. 이 방법에 따르면 5-halo-6-methyluracil이 70% 이상의 좋은 수득률로 얻어지며 부반응을 수반하지 않으므로 생성물의 정제가 쉽고 편리하게 5-halouracil을 얻을 수 있다는 이점이 있다.

Keywords

References

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