Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Reaction of Nitrous Acid on 5-Aminopyrimidines (I) Sandmeyer Reaction of Diazotizated 5-Aminouracil

5-Aminopyrimidine 유도체에 대한 아질산의 작용 [I] Diazotizated 5-Aminouracil에 대한 Sandmeyer 반응

  • Chang, Sae-Hee (Department of Chemistry, College of Liberal Arts and Sciences, Seoul National University) ;
  • Kim, In-Kyu (Department of Chemistry, College of Liberal Arts and Sciences, Seoul National University) ;
  • Park, Do-Soon (Chung Ju Fertilizing Ind.Co. Ltd.) ;
  • Hahn, Bo-Sup (Department of Chemistry, College of Liberal Arts and Sciences, Seoul National University)
  • Published : 19650300
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Abstract

A new conventional method for the preparation of 5-iodo-, chloro-and bromouracil by Sandmeyer reaction was described. According to this procedure, 5-halouracils have been prepared in high yields(up to 75%) without any difficulties to remove of impurities. No appreciable competing reaction was observed.

Sandmeyer 반응으로 5-aminouracil로부터 5-iodo-, 5-chloro-및 5-bromouracil을 간편하게 합성하는 방법을 세로히 마련하였다. 이 방법에 따르면 5-halouracil이 75% 이상의 좋은 수율로 얻어지며, 부반응을 수반하지 않으므로 생성물의 정제가 쉽고 편리하게 5-halouracil을 얻을 수 있다는 이점이 있다.

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References

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