약학회지 (YAKHAK HOEJI)
- 제8권3호
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- Pages.76-79
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- 1964
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
p-Methoxycinnamic Acid의 뇨대사물에 대하여
Urinary Metabolites of p-Methoxycinnamic Acid
초록
The metabolism of p-methoxycinnamic acid (p-MCA) has been studied in man and rabbits. Possible compounds were examined for metabolites by crystalization and by paper chromatography, which excreted after adminstration of p-MCA by stomach tube and intravenous injection. p-Methoxyhippuric acid was isolated from urine. Although pure glucuronide was not crystallized from urine, product was obtained by basic lead salt method, which gave p-methodxybenzoic acid (p-MBA) on hydrolysis and gave an intese naphthoresorcinol reaction. No evidence for the demethylation of p-MCA was found. These results are indicating that p-MCA may be mainly converted to p-MBA by
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