Animal Tests of New 5-Chloro-8-quinolinol Derivatives as Amebicides

5-Chloro-8-Quinolinol 유도체의 항아메바 증제로서의 동물실험

Three new 5-chloro-8-quinolinol derivatives such as 5-chloro-7-[4-(2-N-pyrrolidylethyl)-1-piperidylmethyl]-8-quinolinol 5-chloro-7-[4-(2-N-piperidylethyl)-1-piperidylmethyl]-8-quinolinol and 5-chloro-7-[4-(2-N-morpholinylethyl)-1-piperidylmethyl]-8-quinolinol were synthesized and found to be effective against Entamoeba histolytica in vitro and against experimental intestinal amebiasis in rats.